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Research Associate III/IV - Immunology/Inflammation - 1549Posted by: RegeneronPosted date: Jun-26-2009
Location: Tarrytown, NY 10591
Located in the beautiful Hudson Valley region of New York, Regeneron is a biopharmaceutical Company that discovers, develops, and commercializes therapeutic medicines for the treatment of serious medical conditions. Regeneron currently markets ARCALYST™ (rilonacept) Injection for subcutaneous use for the treatment of a rare, inherited, inflammatory condition. The company has therapeutic candidates in clinical trials for the potential treatment of cancer, eye diseases and inflammatory diseases, and has preclinical programs in other diseases and disorders.
With a strong research base and product focus, Regeneron is able to understand thoroughly the biology of specific disease states, discover potential therapeutic candidates and evaluate product candidates in clinical trials. Regeneron has developed several proprietary platform technologies, which it has incorporated into a comprehensive system that allows it to accelerate the discovery and design of fully human antibodies and move these candidates rapidly into clinical development.
Job Title: Research Associate III/IV - Immunology/Inflammation
Requisition Number: 1549
Location: Tarrytown, NY 10591
The immune group is seeking a motivated and talented Research Associate. The ideal candidate will be part of a highly interactive team. The successful candidate will study mouse phenotyping and disease models to join a highly interactive immunology team. Candidate will be responsible for analysis of knockout mouse phenotypes and disease models, as well as screening antibodies candidates in primary cell based assays and testing novel protein therapeutics in vivo. The job will include design of in vitro cell based assays manipulating mouse and human primary Dendritic and T cells. In addition, the candidate will participate in projects involving Dendritic and T cell responses under steady state or inflammatory condition (TLR and Notch signaling) using multi-color (LSRII) flow cytometry.
Requirement:
- Bachelor's degree
- At least 4-6 years of experience in the field of cellular immunology, including flow cytometry, tissue culture and in vitro cell-based assays of immune function.
- Additional experience in tissue culture (maintenance and transfection of transformed and primary cells), cell-based assays, cytokine ELISA, mouse phenotyping and rodent disease models, western blotting, and flow cytometry are highly desirable
- Basic computer literacy and experience collecting and analyzing biological data on the computer is a necessity
- In vitro and in vivo experimental design, Flow Cytometry (Calibur, LSR), ELISA/ELISPOT, Primary cell culture (Dendritic cells, T cells), DNA cloning, Histology, Immunoprecipitation, Western blot
- In vitro experiments such as antigen presentation assays and research studies, including techniques and methodologies to be used
- In vivo experiments using, mouse disease models, analyzing results, and documenting findings
- Aids in developing novel methodologies or technologies for cell based assays
- Reports research findings and typically contribute to scientific/technical populations or journals
- Develops creativity and implements company practices and priorities to obtain solutions to technical problems
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